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Tomizawa K, et al

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Moderate concentration: 0.5% to 2% The moderate range captures the majority of effective copper peptide products

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Pre-existing risk factors : Individuals with established osteoporosis, previous fragility fractures, advanced age (particularly postmenopausal women), low baseline BMI, or those taking medications that affect bone metabolism (such as corticosteroids) may be more susceptible to bone density changes during weight loss

Renal effects: Rare cases of interstitial nephritis and capillary necrosis have been reported in patients treated with diclofenac